Peripheral Blood Mononuclear Cell Activation Induced by Leptospira interrogans Glycolipoprotein
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چکیده
منابع مشابه
Peripheral blood mononuclear cell activation induced by Leptospira interrogans glycolipoprotein.
Leptospira interrogans glycolipoprotein (GLP) has been implicated in pathological and functional derangement seen in leptospirosis. The goal of this study was to evaluate GLP's ability to induce cellular activation, as assessed by cytokine production and expression of surface activation markers. GLP extracted from either pathogenic L. interrogans serovar Copenhageni or nonpathogenic Leptospira ...
متن کاملLeptospira interrogans activation of peripheral blood monocyte glycolipoprotein demonstrated in whole blood by the release of IL-6.
Glycolipoprotein (GLP) from pathogenic serovars of Leptospira has been implicated in the pathogenesis of leptospirosis by its presence in tissues of experimental animals with leptospirosis, the inhibition of the Na,K-ATPase pump activity, and induced production of cytokines. The aims of the present study were to investigate the induction of IL-6 by GLP in peripheral blood mononuclear cells (PBM...
متن کاملMurine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor
BACKGROUND Leptospiral glycolipoprotein (GLP) is a potent and specific Na/K-ATPase inhibitor. Severe pulmonary form of leptospirosis is characterized by edema, inflammation and intra-alveolar hemorrhage having a dismal prognosis. Resolution of edema and inflammation determines the outcome of lung injury. Na/K-ATPase activity is responsible for edema clearance. This enzyme works as a cell recept...
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Background: Mesenchymal stem cells (MSCs) are important candidates for MSC-based cellular therapy. Current paradigm states that MSCs support local progenitor cells in damaged tissue through paracrine signaling. Therefore, study of paracrine effects and secretome of MSCs could lead to the appreciation of mechanisms and molecules associated with the therapeutic effects of these cells. This study ...
متن کاملSurface colonies of Leptospira interrogans.
Observations of colonial growth of Leptospira interrogans serovar pomona, BJ, on soft-agar (1% agar) plates revealed the presence of both surface and subsurface colonies. The organisms from both types of colonies appeared to be similar in motility, morphology, antigenic composition, and pathogenicity. Passage in vivo tended to produce a higher incidence of surface colonies, whereas passage in v...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2002
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.70.4.1677-1683.2002